Following doses are recommended in the eradication of Helicobacter pylori based on the choice/resistant pattern:
- Zopent gastro-resistant tablet 40 mg twice a day + amoxicillin 1000 mg twice a day + clarithromycin 500 mg twice a day
- Zopent gastro-resistant tablet 40 mg twice a day+ metronidazole 500 mg twice a day + clarithromycin 500 mg twice a day
- Zopent gastro-resistant tablet 40 mg twice a day + amoxicillin 1000 mg twice a day + metronidazole 500 mg twice a day
For duodenal ulcer, gastric ulcer, and reflux esophagitis
Zopent gastro-resistant tablet 40 mg daily. Sometimes the dose may be required to be doubled (increase to 2 gastro-resistant tablets Zopent daily) especially when there has been no response to other treatment.
In hepatic impairment the dose needs to be reduced to 1 tablet (40mg pantoprazole) every other day.
Mild GERD (gastro-esophageal reflux disease)
In patients with mild GERD, 1 Zopent 20mg tablet/day should be given for a period of 4 week. If healing is not complete in 4 weeks, same dose can be continued for further 4 weeks.
Prevention of relapse/long-term management in GERD
For prevention of relapse/ long-term management in GERD the patient should be maintained on 1 Zopent 20mg tablet/day. This may be increased to 40mg/day if relapse occurs. After the relapse is resolved, the dose is to be reduced back to 20mg /day.
In patients with hepatic cirrhosis
In patients with hepatic cirrhosis, dose should not exceed 20mg/day.
In elderly patients or in those with impaired renal function the daily dose of 40mg pantoprazole should not be exceeded. However in eradication of H Pylori combination therapy elderly patients should receive the usual pantoprazole dose (2 x 40mg/day) during 1-week treatment.
Duration of treatment
H. Pylori eradication: Generally the combination therapy is implemented for 7 days in and can be prolonged to up to two weeks maximum. The drug should be used 1 hour before breakfast, the second Zopent tablet should be taken before the evening meal.
Other conditions: A duodenal ulcer generally heals within 2 weeks. If a 2 weeks period of treatment is not sufficient, healing will be achieved in almost all cases within a further 2 week. A 4 week period is usually required for the treatment of gastric ulcers and reflux esophagitis. If this is not sufficient, healing will usually be achieved within a further 4 weeks.
Overdosage
There are no known symptoms of overdosage in man. In the case of overdosage with clinical signs of intoxication, the usual rules of intoxication therapy apply.
