Information for Professionals
Peak serum concentrations of both components are present about one hour after oral administration. Concomitant intake of food does not affect absorption. Amoxi-Clav readily penetrates into tissues, it diffuses through the placenta and only small quantities are transferred into breast milk.
Bio-Availability
The bioavailability of amoxycjllin is approximately 90 % and that of clavulanic acid is approximately 60 %. However the latter is subject to marked fluctuations. The elimination half-life of the two components which are eliminated in practically unchanged form in the urine is about one hour. Urine recovery of amoxycillin ranges between 60 % and 80 % and that of clavulanic acid between 30 % and 50 %.
